5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

Base Information

Chemical Name:5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone
CAS No.:444663-43-8
Molecular Formula:C₁₆H₁₂BrCl₂NO₂
Molecular Weight:401.087
Hs Code.:

Synonyms:5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

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Technology Process of 5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

There total 7 articles about 5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 444663-46-1
N-(2,6-dichlorophenyl)-3-(2,6-dibromo-4-methoxyphenyl)-propionamide

: 444663-43-8
5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

Guidance literature:: With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 155 ℃;
DOI:10.1016/S0960-894X(02)00990-3

Reference yield:

: 14542-71-3
2,6-dibromo-4-methoxytoluene

: 444663-43-8
5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

Guidance literature:: Multi-step reaction with 6 steps

1: NBS; (BzO)2 / CCl₄

2: LHMDS / tetrahydrofuran / -78 °C

3: TFA

4: (COBr)2; DMF / CH₂Cl₂ / -78 - 20 °C

5: DIPEA / CH₂Cl₂

6: 86 percent / CuI; K₂CO₃ / dimethylformamide / 155 °C

With N-Bromosuccinimide; copper(l) iodide; Oxalyl bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; 6: Ullmann cyclization;
DOI:10.1016/S0960-894X(02)00990-3

Reference yield:

: 130445-13-5
1,3-dibromo-2-(bromomethyl)-5-methoxybenzene

: 444663-43-8
5-bromo-1-(2,6-dichlorophenyl)-3,4-dihydro-7-methoxy-2(1H)-quinolinone

Guidance literature:: Multi-step reaction with 5 steps

1: LHMDS / tetrahydrofuran / -78 °C

2: TFA

3: (COBr)2; DMF / CH₂Cl₂ / -78 - 20 °C

4: DIPEA / CH₂Cl₂

5: 86 percent / CuI; K₂CO₃ / dimethylformamide / 155 °C

With copper(l) iodide; Oxalyl bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5: Ullmann cyclization;
DOI:10.1016/S0960-894X(02)00990-3