130445-13-5

Usage

Structure

A benzene ring with two bromine atoms at the 1st and 3rd positions, a bromomethyl group at the 2nd position, and a methoxy group at the 5th position.

Derivative

Benzene

Functional groups

Bromine atoms, methoxy group, and bromomethyl group

Usage

Organic synthesis, reagent in chemical reactions, production of pharmaceuticals, and agrochemicals

Physical state

White to light yellow solid

Safety

Potential health hazards, should be handled with care

Upstream product

• 14542-71-3 2,6-dibromo-4-methoxytoluene 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 

Downstream Products

• 130445-14-6 diethyl 2-acetamido-2-(2',6'-dibromo-4'-methoxybenzyl)malonate 
• 202332-55-6 (3R,6S)-2,5-Dimethoxy-3-isopropyl-6-(2',6'-dibromo-4'-methoxybenzyl)-3,6-dihydropyrazine 
• 444663-44-9 t-butyl 3-(2,6-dibromo-4-methoxyphenyl)-propionate 
• 444663-76-7 (2,6-dibromo-4-methoxy-benzyl)-(4-methoxy-benzyl)-amine 
• 1571136-61-2 2-(2,6-dibromo-4-methoxyphenyl)acetic acid 
• 1571136-62-3 2-(2,6-dibromo-4-methoxyphenyl)-N-methylacetamide 
• 883839-47-2 2-(2,6-dibromo-4-methoxyphenyl)acetonitrile 
• 130445-16-8 N-t-butoxycarbonyl-2,6-dibromo-DL-tyrosine 
• 130445-15-7 2-Amino-3-(2,6-dibromo-4-hydroxy-phenyl)-propionic acid 
• 444664-31-7 4-[1-(2,6-dichloro-phenyl)-5-(2,4-difluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 444663-63-2 7-(1-tert-butoxycarbonyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-2(1H)-quinolinone 
• 444665-24-1 tert-Butyl 4-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl]piperidine-1-carboxylate 

Relevant academic research and scientific papers

Direct one-pot synthesis of naphthoxindoles from 4-bromooxindoles by Suzuki-Miyaura coupling and aldol condensation reactions

An efficient one-pot synthesis of naphthoxindoles by using 4-bromoindolin-2-ones and 2-formylphenylboronic acids has been developed. The coupling reaction proceeds in good to excellent yields under microwave irradiation through a Suzuki-Miyaura coupling a

Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors

Synthesis and biological activities of some quinolinone and dihydroquinolinone p38 MAP kinase inhibitors are reported. Modifications to the dihydroquinolinone pharmacophore revealed that dihydroquinolinone may be replaced with a quinolinone pharmacophore

(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents

Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.

p38 inhibitors: Piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones

We have synthesized a series of C7-piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones that are highly potent inhibitors of both p38 MAP kinase activity and TNF-α release. The 4-aminopentamethylpiperidin

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

The development of potent, orally bioavailable (in rat) and selective dihydroquinazolinone inhibitors of p38α MAP kinase is described. These analogues are hybrids of a pyridinylimidazole p38α inhibitor reported by Merck Research Laboratories and VX-745. O

Synthesis of 3H2-Tyr1>Leucine-enkephalin

The synthesis of 3H2-Tyr1>leucine-enkephalin by the catalytic tritiation of 1>leucine-enkephalin is described.The precursor amino acid, 2,6-dibromo-DL-tyrosine, was synthesized in three step