tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate
CAS No.:1402851-10-8
Molecular Formula:C₁₇H₂₆N₂O₂
Molecular Weight:290.406
Hs Code.:

Synonyms:tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate

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Chemical Property of tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate

There total 19 articles about tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1402850-81-0
tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: 1402851-10-8
tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate

Guidance literature:: With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 20 ℃; for 4h;
DOI:10.1021/ol302459c

Reference yield: 68.0%

: 1402850-81-0
tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: 1402851-09-5
tert-butyl (2S,3R)-6-methyl-3-amino-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: 1402851-10-8
tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate

Guidance literature:: With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 ℃; for 0.333333h;
DOI:10.1021/ol302459c

Reference yield:

: 1402850-61-6
5-nitropent-1-yne

: 1402851-10-8
tert-butyl (2S,3R,6R)-3-amino-6-methyl-2-phenylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: C₁₇H₂₁F₆N₃O / toluene / 24 h / -15 °C / Inert atmosphere; Sealed tube

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: 6 h / 60 °C / Inert atmosphere

2.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 4 h / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; C₁₇H₂₁F₆N₃O; In methanol; toluene;
DOI:10.1021/ol302459c