tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.:1402850-81-0
Molecular Formula:C₁₇H₂₂N₂O₄
Molecular Weight:318.373
Hs Code.:

Synonyms:tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

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Chemical Property of tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

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Technology Process of tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

There total 27 articles about tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1402850-61-6
5-nitropent-1-yne

: 150884-50-7
benzaldehyde N-boc imine

: 1402850-81-0
tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: 5-nitropent-1-yne; benzaldehyde N-boc imine; With C₁₇H₂₁F₆N₃O; In toluene; at -15 ℃; for 24h; Inert atmosphere; Sealed tube;

With diphenyl hydrogen phosphate; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

With Echavarren's catalyst; In toluene; at 40 ℃; for 8h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302459c

Reference yield:

: 1402850-61-6
5-nitropent-1-yne

: 150884-50-7
benzaldehyde N-boc imine

: 1402850-81-0
tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: tert-butyl 6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: 5-nitropent-1-yne; benzaldehyde N-boc imine; With C₁₇H₂₁F₆N₃O; In toluene; at -15 ℃; for 24h; Inert atmosphere; Sealed tube;

With diphenyl hydrogen phosphate; In toluene; at 20 ℃; for 0.5h; Inert atmosphere;

With Echavarren's catalyst; In toluene; at 60 ℃; for 6h; Overall yield = 65 %; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol302459c

Reference yield:

: C₁₇H₂₂N₂O₄

: 1402850-81-0
tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: tert-butyl (2R,3S)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: 1402851-07-3
tert-butyl (2S,3S)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: tert-butyl (2R,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With Echavarren's catalyst; In toluene; at 100 ℃; for 24h; Overall yield = 57 %; Overall yield = 3.2 mg; Inert atmosphere; Sealed tube;
DOI:10.1021/ol302459c