ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate
CAS No.:1251469-30-3
Molecular Formula:C₂₃H₁₉ClFN₃O₂
Molecular Weight:423.874
Hs Code.:

Synonyms:ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate

There total 1 articles about ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 23834-14-2
7-chloro-4-hydrazinoquinoline

: 36967-50-7
ethyl 2-acetyl-4-(4-fluorophenyl)-4-oxobutanoate

: 1251469-30-3
ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate

Guidance literature:: 7-chloro-4-hydrazinoquinoline; ethyl 2-acetyl-4-(4-fluorophenyl)-4-oxobutanoate; With acetic acid; for 2h; Reflux; Inert atmosphere;

With sodium hydroxide;
DOI:10.1016/j.bmc.2010.08.001

Reference yield: 45.0%

: 123-75-1
pyrrolidine

: 1251469-30-3
ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate

: 1251469-36-9
[1-((7-chloroquinolin-4-yl)amino)-5-(4-fluorophenyl)-2-methyl-1H-pyrrol-3-yl](pyrrolidin-1-yl)methanone

Guidance literature:: pyrrolidine; With trimethylaluminum; In toluene; at 20 ℃; Cooling with ice; Inert atmosphere;

ethyl 1-[(7-chloroquinolin-4-yl)amino]-2-methyl-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate; In toluene; at 150 ℃; for 0.583333h; Microwave irradiation;
DOI:10.1016/j.bmc.2010.08.001