(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile

Base Information

Chemical Name:(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile
CAS No.:1432725-69-3
Molecular Formula:C₁₉H₁₂BrF₃N₂O
Molecular Weight:421.216
Hs Code.:

Synonyms:(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile

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Chemical Property of (2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile

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Technology Process of (2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile

There total 2 articles about (2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 732306-26-2
2-(2-bromo-5-(trifluoromethyl)phenyl)acetonitrile

: 952569-54-9
1-iodo-7-methoxyisoquinoline

: 1432725-69-3
(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile

Guidance literature:: With sodium amide; In tetrahydrofuran; Reflux; Inert atmosphere; Cooling with ice;
DOI:10.1021/jo400645g

Reference yield:

: 16027-16-0
7-methoxy-2H-isoquinolin-1-one

: 1432725-69-3
(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoromethylsulfonic anhydride; pyridine / acetonitrile / 2 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium amide / tetrahydrofuran / Reflux; Inert atmosphere; Cooling with ice

With pyridine; trifluoromethylsulfonic anhydride; sodium amide; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo400645g

Reference yield: 74.0%

: 1432725-69-3
(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile

: 1432725-86-4
(2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)methanone

Guidance literature:: (2-bromo-5-trifluoromethylphenyl)(7-methoxyisoquinolin-1-yl)acetonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

With oxygen; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jo400645g