methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Base Information

Chemical Name:methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate
CAS No.:1380754-97-1
Molecular Formula:C₂₈H₂₈ClFN₄O₃
Molecular Weight:523.007
Hs Code.:

Synonyms:methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

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Chemical Property of methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

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Technology Process of methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

There total 6 articles about methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380752-59-9
tert-butyl 3-((4-fluoro-2-methylphenyl)amino)azetidine-1-carboxylate

: 1380754-97-1
methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: triethylamine / tetrahydrofuran; methanol / 12 h / 75 °C

4.1: water; sodium hydroxide / 1,4-dioxane / 2 h / 60 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 2 h / 20 °C

With water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 452-71-1
4-fluor-2-methylaniline

: 1380754-97-1
methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

2.1: acetic acid; sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: triethylamine / tetrahydrofuran; methanol / 12 h / 75 °C

5.1: water; sodium hydroxide / 1,4-dioxane / 2 h / 60 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 2 h / 20 °C

With water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1380752-67-9
tert-butyl 3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidine-1-carboxylate

: 1380754-97-1
methyl 4-(1-(5-chloro-2-(3-((4-fluoro-2-methylphenyl)(methyl)amino)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.1: triethylamine / tetrahydrofuran; methanol / 12 h / 75 °C

3.1: water; sodium hydroxide / 1,4-dioxane / 2 h / 60 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 2 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;