methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester

Base Information

• Chemical Name: methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester
• CAS No.: 886227-41-4
• Molecular Formula: C₉H₁₂FO₂PS
• Molecular Weight: 234.231
• Mol file: 886227-41-4.mol

Synonyms:methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester

Chemical Property of methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester

There total 1 articles about methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorothiophenol (371-42-6) → methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester (886227-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24 h / 20 °C

2: Na₂CO₃ / tetrahydrofuran / 0.5 h

With sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1002/anie.200503182

Reference yield:

methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester (886227-41-4) + sodium methylate (124-41-4) → 4-Fluorothiophenol (371-42-6) + O-ethyl O-methyl methylphosphonate (18755-36-7)

Guidance literature:

With N-ethylmorpholine;; perchloric acid; sodium methylate; La(OTf); In methanol; Title compound not separated from byproducts;

DOI:10.1002/anie.200503182

upstream raw materials:

4-Fluorothiophenol

Downstream raw materials:

4-Fluorothiophenol

O-ethyl O-methyl methylphosphonate