N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide
• CAS No.: 773056-51-2
• Molecular Formula: C₁₄H₁₉NO₃S
• Molecular Weight: 281.376
• Mol file: 773056-51-2.mol

Synonyms:N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide

Chemical Property of N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide

There total 1 articles about N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-N-(2-propenyl)benzenesulfonamide (50487-71-3) → N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide (773056-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 25 °C

1.2: 85 percent / dimethylformamide / 12 h / 25 °C

2.1: 74 percent / DIBAL-H / diethyl ether / -78 - 25 °C

With sodium hydride; diisobutylaluminium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jo048990k

Reference yield: 63.0%

N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide (773056-51-2) → [1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]methanol (773056-52-3)

Guidance literature:

Grubbs catalyst first generation; In dichloromethane; at 40 ℃; for 34h;

DOI:10.1021/jo048990k

Reference yield:

N-allyl-N-(2-hydroxymethylallyl)-4-methylbenzenesulfonamide (773056-51-2) → carbamic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester (773056-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / Grubbs' catalyst / CH₂Cl₂ / 34 h / 40 °C

2: CH₂Cl₂ / 3 h / 20 °C

3: K₂CO₃ / methanol / 2 h / 25 °C

With potassium carbonate; Grubbs catalyst first generation; In methanol; dichloromethane;

DOI:10.1021/jo048990k

upstream raw materials:

4-methyl-N-(2-propenyl)benzenesulfonamide

Downstream raw materials:

[1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]methanol

carbamic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester