Technology Process of (2R)-2-benzyl-3,3,3-trifluoropropanoic acid
There total 5 articles about (2R)-2-benzyl-3,3,3-trifluoropropanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4R)-3-[(2R)-2-benzyl-3,3,3-trifluoropropanoyl]-4-phenyl-1,3-oxazolidin-2-one;
With
dihydrogen peroxide; lithium hydroxide;
In
tetrahydrofuran; water;
at 0 ℃;
Inert atmosphere;
With
sodium sulfite;
In
tetrahydrofuran; water;
Inert atmosphere;
With
hydrogenchloride;
In
water;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1021/ol2023328
- Guidance literature:
-
With
morpholine; bis(1,5-cyclooctadiene)rhodium(I) hexafluorophosphate; C24H21O3P; triphenylphosphine;
In
chloroform; water;
at 20 ℃;
for 16h;
under 15201 Torr;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/anie.201307903
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 6 h / -78 - 20 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 - 20 °C / Inert atmosphere
3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C / Inert atmosphere
3.2: Inert atmosphere
3.3: Inert atmosphere
With
n-butyllithium; dihydrogen peroxide; lithium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; water;
DOI:10.1021/ol2023328
![(4R)-3-[(2R)-2-benzyl-3,3,3-trifluoropropanoyl]-4-phenyl-1,3-oxazolidin-2-one](/Databaselist/images/loading.webp)
