2-Oxazolidinone, 3-(1-oxo-3-phenylpropyl)-4-phenyl-, (4R)-

Base Information

• Chemical Name: 2-Oxazolidinone, 3-(1-oxo-3-phenylpropyl)-4-phenyl-, (4R)-
• CAS No.: 220041-91-8
• Molecular Formula: C18H17NO3
• Molecular Weight: 295.338
• Mol file: 220041-91-8.mol

Synonyms:3-(3-phenylpropanoyl)-(4R)-phenyl-2-oxazolidinone;(4R)-3-(3-phenylpropanoyl)-4-phenyl-2-oxazolidinone;(4R)-3-phenylpropanoyl-4-phenyl-1,3-oxazolidin-2-one;

Chemical Property of 2-Oxazolidinone, 3-(1-oxo-3-phenylpropyl)-4-phenyl-, (4R)-

Chemical Property:

• Melting Point: 126-127 °C
• Boiling Point: 499.6±44.0 °C(Predicted)
• PSA: 46.61000
• Density: 1.230±0.06 g/cm3(Predicted)
• LogP: 3.27720

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Oxazolidinone, 3-(1-oxo-3-phenylpropyl)-4-phenyl-, (4R)-

There total 5 articles about 2-Oxazolidinone, 3-(1-oxo-3-phenylpropyl)-4-phenyl-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4R)-phenyl-2-oxazolidinone (90319-52-1,7480-32-2) + hydrocinnamic acid chloride (645-45-4) → (R)-4-phenyl-N-(3'-phenylpropanoyl)-1,3-oxazolidin-2-one (220041-91-8)

Guidance literature:

(4R)-phenyl-2-oxazolidinone; With tetraethylammonium perchlorate; In acetonitrile; at 20 ℃; Electrochemical reaction;

hydrocinnamic acid chloride; With tetraethylammonium perchlorate; In acetonitrile; at 20 ℃; for 3h; Further stages.;

DOI:10.1021/jo016323a

Reference yield: 87.0%

(4R)-phenyl-2-oxazolidinone (90319-52-1,7480-32-2) + 3-Phenylpropionic acid (501-52-0) → (R)-4-phenyl-N-(3'-phenylpropanoyl)-1,3-oxazolidin-2-one (220041-91-8)

Guidance literature:

With pivaloyl chloride; triethylamine; In toluene; at 110 ℃; for 14h;

DOI:10.1016/S0040-4039(98)02112-1

Reference yield: 10.0%

carbon dioxide (124-38-9,18923-20-1) + (4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone (155835-37-3) → 4-Oxo-4-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-2-phenyl-butyric acid + (4R)-phenyl-2-oxazolidinone (90319-52-1,7480-32-2) + (R)-4-phenyl-N-(3'-phenylpropanoyl)-1,3-oxazolidin-2-one (220041-91-8)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In N,N-dimethyl-formamide; at -20 ℃; Electrochemical reaction;

DOI:10.1039/b500570a

upstream raw materials:

(4R)-phenyl-2-oxazolidinone

3-Phenylpropionic acid

hydrocinnamic acid chloride

carbon dioxide

Downstream raw materials:

ethyl 2-((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetate hydrochloride

ethyl N-[(2S)-2-benzyl-3-hydroxypropanoyl]glycinate

Entereg

(S)-2-hydroxymethyl-3-phenylpropionic acid