N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Base Information

Chemical Name:N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine
CAS No.:1288960-56-4
Molecular Formula:C₂₂H₂₅Cl₂N₃O₂
Molecular Weight:434.365
Hs Code.:

Synonyms:N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

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Chemical Property of N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

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Technology Process of N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

There total 4 articles about N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1288961-12-5
tert-butyl (cyclopropylmethyl)[3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazol-7-yl]carbamate

: 1288960-56-4
N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: tert-butyl (cyclopropylmethyl)[3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazol-7-yl]carbamate; With trifluoroacetic acid; In dichloromethane; at 10 - 35 ℃; for 2.16667h;

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde; With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 10 - 35 ℃; for 1h;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 1288960-98-4
ethyl 3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazole-7-carboxylate

: 1288960-56-4
N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 3.5 h / 60 - 85 °C

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 1.33 h / 110 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 10 - 35 °C

4.1: trifluoroacetic acid / dichloromethane / 2.17 h / 10 - 35 °C

4.2: 1 h / 10 - 35 °C

With diphenyl phosphoryl azide; water; sodium hydride; triethylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1288961-01-2
3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazole-7-carboxylic acid

: 1288960-56-4
N-(cyclopropylmethyl)-3-(2,4-dichlorophenyl)-6-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1.33 h / 110 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 10 - 35 °C

3.1: trifluoroacetic acid / dichloromethane / 2.17 h / 10 - 35 °C

3.2: 1 h / 10 - 35 °C

With diphenyl phosphoryl azide; sodium hydride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;