Technology Process of ethyl 3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazole-7-carboxylate
There total 3 articles about ethyl 3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazole-7-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-ethoxycarbonyl-3-methyl-3-pyrazolin-5-one;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 0.166667h;
2,4-dichlorophenacyl bromide;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 1h;
With
toluene-4-sulfonic acid; acetic acid;
In
toluene;
at 120 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrazine hydrochloride / ethanol / 10 h / 85 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 50 °C
2.2: 1 h / 50 °C
2.3: 5 h / 120 °C
With
hydrazine hydrochloride; potassium carbonate;
In
ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrachloromethane; magnesium / toluene; ethanol / 1.5 h / 10 - 85 °C
1.2: 72.5 h / 0 - 35 °C
1.3: 0 °C
2.1: hydrazine hydrochloride / ethanol / 10 h / 85 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 50 °C
3.2: 1 h / 50 °C
3.3: 5 h / 120 °C
With
tetrachloromethane; hydrazine hydrochloride; potassium carbonate; magnesium;
In
ethanol; N,N-dimethyl-formamide; toluene;
