2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide

Base Information

• Chemical Name: 2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide
• CAS No.: 888408-66-0
• Molecular Formula: C₂₈H₅₂N₁₀O₂
• Molecular Weight: 560.787

Synonyms:2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide

Chemical Property of 2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide

Chemical Property:

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Technology Process of 2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide

There total 2 articles about 2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1,4-bis(2-chloro-acetylamino)-xylylene → 2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide (888408-66-0)

Guidance literature:

With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 85 ℃; for 40h;

DOI:10.1039/b514106k

Reference yield:

p-xylylidenediamine (539-48-0) → 2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide (888408-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaOH / H₂O

2: 41 percent / Cs₂CO₃; KI / dimethylformamide / 40 h / 85 °C

With sodium hydroxide; caesium carbonate; potassium iodide; In water; N,N-dimethyl-formamide;

DOI:10.1039/b514106k

Reference yield: 57.0%

2-(1,4,7,10-tetraazacyclododec-1-yl)-N-{4-[2-(1,4,7,10-tetraazacyclododec-1-yl-acetylamino)methyl]benzyl}acetamide (888408-66-0) + bromo-acetic acid amide (683-57-8) → 2-(4,10-bis-carbamoylmethyl-7-[(4-([2-(4,7,10-triscarbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-acetylamino]methyl)benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododec-1-yl)acetamide (888408-39-7)

Guidance literature:

With triethylamine; In ethanol; at 85 ℃; for 40h;

DOI:10.1039/b514106k

upstream raw materials:

p-xylylidenediamine

Downstream raw materials:

2-(4,7-bis-methylcarbamoylmethyl-10-[(4-([2-(4,7,10-triscarbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-acetylamino]methyl)benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododec-1-yl)acetamide

2-(4,10-bis-dimethylcarbamoylmethyl-7-[(4-([2-(4,7,10-triscarbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-acetylamino]methyl)benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododec-1-yl)-N,N-dimethylacetamide

2-(4,10-bis-carbamoylmethyl-7-[(4-([2-(4,7,10-triscarbamoylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-acetylamino]methyl)benzylcarbamoyl)methyl]-1,4,7,10-tetraazacyclododec-1-yl)acetamide

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