N-benzyl-N-(tert-butoxycarbonyl)-N-amine

Base Information

• Chemical Name: N-benzyl-N-(tert-butoxycarbonyl)-N-amine
• CAS No.: 148638-79-3
• Molecular Formula: C₁₈H₂₇NO₄
• Molecular Weight: 321.417
• Mol file: 148638-79-3.mol

Synonyms:N-benzyl-N-(tert-butoxycarbonyl)-N-amine

Chemical Property of N-benzyl-N-(tert-butoxycarbonyl)-N-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-N-(tert-butoxycarbonyl)-N-amine

There total 5 articles about N-benzyl-N-(tert-butoxycarbonyl)-N-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + N-benzyl-N-amine (109208-40-4) → N-benzyl-N-(tert-butoxycarbonyl)-N-amine (148638-79-3)

Guidance literature:

With dmap; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1016/0040-4020(96)00309-2

Reference yield:

2,3-isopropylidene-glyceraldehyde (15186-48-8) → N-benzyl-N-(tert-butoxycarbonyl)-N-amine (148638-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / magnesium sulfate / diethyl ether / 3 h

2: NaBH₄ / methanol / 0.5 h / 0 °C

3: 80 percent / DMAP / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; sodium tetrahydroborate; magnesium sulfate; In methanol; diethyl ether; dichloromethane;

DOI:10.1016/0040-4020(96)00309-2

Reference yield:

1,2:5,6-di-O-isopropylidene-D-mannitol (1707-77-3) → N-benzyl-N-(tert-butoxycarbonyl)-N-amine (148638-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaIO₄ / H₂O / 1 h / 5 - 10 °C

2: 100 percent / H₂ / Raney Ni / H₂O; ethanol / 8 h / 5 - 10 °C

3: 78 percent / Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

With sodium periodate; hydrogen; triethylamine; nickel; In ethanol; dichloromethane; water;

upstream raw materials:

di-tert-butyl dicarbonate

N-benzyl-N-amine

(R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine

benzylamine

Downstream raw materials:

N-benzyl-N-(tert-butoxycarbonyl)-N-<2(S),3-dihydroxypropyl>amine

(S)-3-Benzyl-2-oxo-oxazolidine-5-carbaldehyde

(5S)-3-benzyl-5-hydroxymethyloxazolidin-2-one

N-Benzyl-2-chloro-N-((R)-2,3-dihydroxy-propyl)-acetamide