(R)-2-Formyl-3-methyl-2-phenyl-butyronitrile

Base Information

Chemical Name:(R)-2-Formyl-3-methyl-2-phenyl-butyronitrile
CAS No.:458557-61-4
Molecular Formula:C₁₂H₁₃NO
Molecular Weight:187.241
Hs Code.:

Synonyms:(R)-2-Formyl-3-methyl-2-phenyl-butyronitrile

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Chemical Property of (R)-2-Formyl-3-methyl-2-phenyl-butyronitrile

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Technology Process of (R)-2-Formyl-3-methyl-2-phenyl-butyronitrile

There total 7 articles about (R)-2-Formyl-3-methyl-2-phenyl-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350795-06-1
(2R)-2-hydroxymethyl-2-isopropyl-2-phenylacetonitrile

: 458557-61-4
(R)-2-Formyl-3-methyl-2-phenyl-butyronitrile

Guidance literature:: With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1021/jo020166d

Reference yield:

: 4-methyl-2-phenylpent-2-en-1-ol

: 458557-61-4
(R)-2-Formyl-3-methyl-2-phenyl-butyronitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 84.1 percent / diethyl L-(+)-tartrate; titanium tetraisopropoxide; molecular sieves 4 Angstroem / tert-butyl hydroperoxide / CH₂Cl₂ / 15 h / -20 °C

2: 100 percent / imidazole / dimethylformamide / 6 h / 20 °C

3: 99 percent / methyl aluminum bis(4-methyl-2,6-di-tert-butylphenoxide) / CH₂Cl₂; toluene / 1 h / -78 °C

4: NH₂OH*HCl; NaOAc / ethanol / 2 h / 20 °C

5: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

6: 2.88 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7: triethylamine; SO₃-pyridine complex / dimethylsulfoxide / 2 h / 20 °C

With 1H-imidazole; titanium(IV) isopropylate; pyridine-SO₃ complex; diethyl (2R,3R)-tartrate; 4 A molecular sieve; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; triethylamine; 1,1'-carbonyldiimidazole; tert.-butylhydroperoxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo020166d

Reference yield:

: 350795-03-8
(2S,3S)-3-isopropyl-2-phenyl-2,3-epoxypropan-1-ol

: 458557-61-4
(R)-2-Formyl-3-methyl-2-phenyl-butyronitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / imidazole / dimethylformamide / 6 h / 20 °C

2: 99 percent / methyl aluminum bis(4-methyl-2,6-di-tert-butylphenoxide) / CH₂Cl₂; toluene / 1 h / -78 °C

3: NH₂OH*HCl; NaOAc / ethanol / 2 h / 20 °C

4: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

5: 2.88 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6: triethylamine; SO₃-pyridine complex / dimethylsulfoxide / 2 h / 20 °C

With 1H-imidazole; pyridine-SO₃ complex; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo020166d