(S)-4-cyano-5-methyl-4-phenylhexyl mesylate

Base Information

Chemical Name:(S)-4-cyano-5-methyl-4-phenylhexyl mesylate
CAS No.:493006-79-4
Molecular Formula:C₁₅H₂₁NO₃S
Molecular Weight:295.403
Hs Code.:

Synonyms:(S)-4-cyano-5-methyl-4-phenylhexyl mesylate

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Chemical Property of (S)-4-cyano-5-methyl-4-phenylhexyl mesylate

Chemical Property:

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Technology Process of (S)-4-cyano-5-methyl-4-phenylhexyl mesylate

There total 17 articles about (S)-4-cyano-5-methyl-4-phenylhexyl mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 350795-08-3
(2S)-2-(2-isopropyl)-5-hydroxy-2-phenylpentanenitrile

: 493006-79-4
(S)-4-cyano-5-methyl-4-phenylhexyl mesylate

Guidance literature:: With triethylamine; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/S0957-4166(02)00364-6

Reference yield:

: 350795-03-8
(2S,3S)-3-isopropyl-2-phenyl-2,3-epoxypropan-1-ol

: 493006-79-4
(S)-4-cyano-5-methyl-4-phenylhexyl mesylate

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / imidazole / dimethylformamide / 6 h / 20 °C

2: 99 percent / methyl aluminum bis(4-methyl-2,6-di-tert-butylphenoxide) / CH₂Cl₂; toluene / 1 h / -78 °C

3: NH₂OH*HCl; NaOAc / ethanol / 2 h / 20 °C

4: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

5: 2.88 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6: triethylamine; SO₃-pyridine complex / dimethylsulfoxide / 2 h / 20 °C

7: 2.72 g / NaH / tetrahydrofuran / 4 h / 20 °C

8: 97 percent / H₂ / Pd/C / ethyl acetate / 16 h / 760.05 Torr

9: 97 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

10: triethylamine / acetonitrile / 2 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; pyridine-SO₃ complex; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; sodium hydride; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo020166d

Reference yield:

: 4-methyl-2-phenylpent-2-en-1-ol

: 493006-79-4
(S)-4-cyano-5-methyl-4-phenylhexyl mesylate

Guidance literature:: Multi-step reaction with 11 steps

1: 84.1 percent / diethyl L-(+)-tartrate; titanium tetraisopropoxide; molecular sieves 4 Angstroem / tert-butyl hydroperoxide / CH₂Cl₂ / 15 h / -20 °C

2: 100 percent / imidazole / dimethylformamide / 6 h / 20 °C

3: 99 percent / methyl aluminum bis(4-methyl-2,6-di-tert-butylphenoxide) / CH₂Cl₂; toluene / 1 h / -78 °C

4: NH₂OH*HCl; NaOAc / ethanol / 2 h / 20 °C

5: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating

6: 2.88 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7: triethylamine; SO₃-pyridine complex / dimethylsulfoxide / 2 h / 20 °C

8: 2.72 g / NaH / tetrahydrofuran / 4 h / 20 °C

9: 97 percent / H₂ / Pd/C / ethyl acetate / 16 h / 760.05 Torr

10: 97 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

11: triethylamine / acetonitrile / 2 h / 0 °C

With 1H-imidazole; titanium(IV) isopropylate; lithium aluminium tetrahydride; pyridine-SO₃ complex; diethyl (2R,3R)-tartrate; 4 A molecular sieve; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum; sodium hydride; triethylamine; 1,1'-carbonyldiimidazole; tert.-butylhydroperoxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jo020166d