phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone

Base Information

Chemical Name:phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone
CAS No.:366454-61-7
Molecular Formula:C₂₆H₃₂O₃SSi
Molecular Weight:452.69
Hs Code.:

Synonyms:phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone

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Chemical Property of phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone

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Technology Process of phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone

There total 5 articles about phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 366454-91-3
phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfide

: 366454-61-7
phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 20 ℃; for 21h;
DOI:10.1021/ja011256n

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 366454-61-7
phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 4 h

2: CaCl₂; NaBH₄ / tetrahydrofuran; diethyl ether / 0 - 20 °C

3: n-Bu₃P / benzene / 2.5 h / 20 °C

4: Oxone / tetrahydrofuran; methanol; H₂O / 24 h / 20 °C

With 1H-imidazole; Oxone; sodium tetrahydroborate; tributylphosphine; calcium chloride; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo0503862

Reference yield:

: 143088-61-3
(2S)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropane

: 366454-61-7
phenyl[(2S)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropan-1-yl]sulfone

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaOH / methanol / 0.42 h / 20 °C

1.2: 100 percent / methanol; tetrahydrofuran / 22 h

2.1: 81 percent / NaHCO₃; m-CPBA / CH₂Cl₂; H₂O / 21 h / 20 °C

With sodium hydroxide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water;
DOI:10.1021/ja011256n