Technology Process of (7S,9RS,11S)-7,11-dimethyl-9-phenylsulfonylheptadecane
There total 7 articles about (7S,9RS,11S)-7,11-dimethyl-9-phenylsulfonylheptadecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dilithium tetrachlorocuprate / tetrahydrofuran / 38 h / -78 - 0 °C
2.1: 91 percent / p-TsOH / methanol / 3 h / 70 °C
3.1: 100 percent / pyridine
4.1: sodium iodide / acetone / 20 h / Heating
5.1: hexamethylphosphoric triamide; nBuLi / tetrahydrofuran / -78 - -30 °C
5.2: 76 percent / tetrahydrofuran / 24 h / -78 - 20 °C
6.1: hexamethylphosphoric triamide; nBuLi / tetrahydrofuran / -78 °C
6.2: 82 percent / tetrahydrofuran / 2 h / -78 - 20 °C
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; dilithium tetrachlorocuprate; toluene-4-sulfonic acid; sodium iodide;
In
tetrahydrofuran; methanol; acetone;
1.1: Substitution / 2.1: Hydrolysis / 3.1: Tosylation / 4.1: Substitution / 5.1: Metallation / 5.2: Substitution / 6.1: Metallation / 6.2: Substitution;
DOI:10.1002/(SICI)1099-0690(199911)1999:11<3139::AID-EJOC3139>3.0.CO;2-8
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 100 percent / pyridine
2.1: sodium iodide / acetone / 20 h / Heating
3.1: hexamethylphosphoric triamide; nBuLi / tetrahydrofuran / -78 - -30 °C
3.2: 76 percent / tetrahydrofuran / 24 h / -78 - 20 °C
4.1: hexamethylphosphoric triamide; nBuLi / tetrahydrofuran / -78 °C
4.2: 82 percent / tetrahydrofuran / 2 h / -78 - 20 °C
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium iodide;
In
tetrahydrofuran; acetone;
1.1: Tosylation / 2.1: Substitution / 3.1: Metallation / 3.2: Substitution / 4.1: Metallation / 4.2: Substitution;
DOI:10.1002/(SICI)1099-0690(199911)1999:11<3139::AID-EJOC3139>3.0.CO;2-8
