C₁₄H₈FIN₂O₃

Base Information

• Chemical Name: C₁₄H₈FIN₂O₃
• CAS No.: 1009335-01-6
• Molecular Formula: C₁₄H₈FIN₂O₃
• Molecular Weight: 398.132
• Mol file: 1009335-01-6.mol

Synonyms:C₁₄H₈FIN₂O₃

Chemical Property of C₁₄H₈FIN₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₈FIN₂O₃

There total 5 articles about C₁₄H₈FIN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(2-fluoro-4-iodo-phenylamino)-furo[3,2-c]pyridine-2-carboxylate (1009333-61-2) → C14H8FIN2O3 (1009335-01-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 65 ℃; for 1.5h;

DOI:10.1158/1535-7163.MCT-12-0949

Reference yield:

ethyl 3-(trifluoromethanesulfonyloxy)-furo[3,2-c]pyridine-2-carboxylate (1009333-55-4) → C14H8FIN2O3 (1009335-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; potassium phosphate / 24 h / 105 °C

2: silver tetrafluoroborate; Iodine monochloride / dichloromethane / 1 h / -50 °C

3: sodium hydroxide / ethanol / 1.5 h / 65 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; silver tetrafluoroborate; Iodine monochloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1158/1535-7163.MCT-12-0949

Reference yield:

ethyl 4-chloronicotinate (37831-62-2) → C14H8FIN2O3 (1009335-01-6)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 0.58 h / 95 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium phosphate / 24 h / 105 °C

4: silver tetrafluoroborate; Iodine monochloride / dichloromethane / 1 h / -50 °C

5: sodium hydroxide / ethanol / 1.5 h / 65 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; silver tetrafluoroborate; Iodine monochloride; sodium hydride; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1158/1535-7163.MCT-12-0949

upstream raw materials:

ethyl 3-(4-trimethylsilyl-2-fluoro-phenylamino)-furo[3,2-c]pyridine-2-carboxylate

ethyl 3-(2-fluoro-4-iodo-phenylamino)-furo[3,2-c]pyridine-2-carboxylate

ethyl 4-chloronicotinate

ethyl 3-hydroxyfuro<3,2-c>pyridine-2-carboxylate