37831-62-2

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-NICOTINIC ACID ETHYL ESTER HYDROCHLORIDE is used as a synthetic intermediate for the development of nicotinamide analogs and 4-Benzofuranyloxynicotinamide derivatives. These compounds hold potential as therapeutic agents, making the ester hydrochloride a crucial component in the creation of novel pharmaceuticals aimed at treating various health conditions.

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 

Downstream Products

• 189449-41-0 4-chloro-3-(hydroxymethyl)pyridine 
• 174496-99-2 ethyl 4-chloropyridine-3-carboxylate hydrochloride 
• 32923-72-1 C₁₂H₈FNO₂ 
• 1491169-00-6 4-(2,6-difluorophenyl)nicotinic acid ethyl ester 
• 1415407-47-4 4-(2,5-dichlorophenoxy)nicotinic acid ethyl ester 

Relevant academic research and scientific papers

NATURE OF THE REDUCING AGENT AND MECHANISM OF THE REDUCTIVE CONDENSATION OF TRICHLOROMETHYLARENES WITH HYDROXYLAMINE AND HYDRAZINES IN PYRIDINE

It was shown that during the reductive condensation of trichloromethylarenes with hydroxylamine or hydrazines in pyridine the event of reduction with replacement of one chlorine atom by a hydrogen atom occurs without the participation of hydroxylamine or hydrazine.The first step of the reaction is the formation of N-(α,α-dichloroarylmethyl)pyridinium chlorides, which are converted by the action of the chloride anion or a second pyridine molecule to the corresponding 4-substituted 1,4-dihydropyridines.The latter undergo further aromatization with transfer of hydrogen from the 4-position of the dihydropyridine ring to the benzyl dichloromethylene group and the formation of N-(α-chloroarylmethyl)-4-chloropyridinium chlorides or N-(α-chloroarylmethyl)-4-(pyridino)pyridinium dichlorides, which give the corresponding aldehydes in hydrolysis or products of reductive condensation under the action of hydroxylamine or hydrazines.