[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

Base Information

Chemical Name:[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride
CAS No.:1083092-38-9
Molecular Formula:C₃₁H₄₂ClN₅O₇S*ClH
Molecular Weight:700.684
Hs Code.:

[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

Synonyms:[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

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Chemical Property of [(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

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Technology Process of [(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

There total 10 articles about [(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083092-37-8
[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-(tert-butoxycarbonyl)-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate

: 1083092-38-9
[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2.5h;

Reference yield:

: 159622-10-3,213316-50-8,259221-77-7
(1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid

: 1083092-38-9
[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium hydroxide on carbon / tert-butyl methyl ether / 5 h / 20 °C / 760.05 Torr

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 20 - 60 °C

2.2: 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

4.2: pH 3 - 4

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 0 - 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-carbonyldiimidazole; palladium hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 923591-24-6
(1R,2R)-1-amino-N-(cyclopropylsulfonyl)-2-ethylcyclopropanecarboxamide hydrochloride

: 1083092-38-9
[(3R,5S)-5-(((1R,2R)-1-(cyclopropylsulfonylcarbamoyl)-2-ethylcyclopropyl)carbamoyl)-1-((S)-2-amino-2-cyclohexylacetyl)pyrrolidin-3-yl] 4-chloroisoindoline-2-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

1.2: pH 3 - 4

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;