diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate

Base Information

Chemical Name:diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate
CAS No.:417712-17-5
Molecular Formula:C₂₁H₃₅O₄P
Molecular Weight:382.48
Hs Code.:

Synonyms:diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate

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Chemical Property of diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate

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Technology Process of diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate

There total 4 articles about diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 104-53-0
3-phenyl-propionaldehyde

: 417712-01-7
(E)-diisopropyl 3,3-dimethylbut-1-en-1-ylphosphonate

: 417712-17-5
diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate

Guidance literature:: (E)-diisopropyl 3,3-dimethylbut-1-en-1-ylphosphonate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

3-phenyl-propionaldehyde; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)01089-4

Reference yield:

: 1660-95-3
Tetraisopropyl methylenediphosphonate

: 417712-17-5
diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / 0.5 h / 0 °C

1.2: 83 percent / 0.33 h / 0 °C

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 99 percent / tetrahydrofuran / 0.25 h / -78 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/S0040-4020(01)01089-4

Reference yield:

: 630-19-3
pivalaldehyde

: 417712-17-5
diisopropyl (E)-1-(1-hydroxy-3-phenylpropyl)-3,3-dimethyl-1-butenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / 0.5 h / 0 °C

1.2: 83 percent / 0.33 h / 0 °C

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 99 percent / tetrahydrofuran / 0.25 h / -78 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/S0040-4020(01)01089-4