Technology Process of N-benzoyl-3-bromoisonicotinamide
There total 1 articles about N-benzoyl-3-bromoisonicotinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-bromopyridine-4-carboxamide;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 1h;
Inert atmosphere;
benzoyl chloride;
In
tetrahydrofuran; mineral oil;
at -78 - 50 ℃;
Inert atmosphere;
DOI:10.1021/ol401516e
- Guidance literature:
-
With
sodium hydride;
In
1-methyl-pyrrolidin-2-one; mineral oil;
at 20 ℃;
for 0.5h;
Solvent;
Concentration;
Temperature;
Time;
Reagent/catalyst;
Inert atmosphere;
DOI:10.1021/ol401516e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / mineral oil; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C / Inert atmosphere
2: dimethyl sulfoxide / 0.5 h / 180 °C / Microwave irradiation
3: triethylamine / ethanol / 0.5 h / 110 °C / Sealed tube; Inert atmosphere
With
sodium hydride; triethylamine;
In
1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide; mineral oil;
DOI:10.1021/ol401516e
