Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester
CAS No.:210834-68-7
Molecular Formula:C₂₈H₃₂F₃NO₆S₂
Molecular Weight:599.692
Hs Code.:

Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Synonyms:Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

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Technology Process of Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

There total 13 articles about Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210834-67-6
Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

: 210834-68-7
Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Yield given;
DOI:10.1016/S0040-4039(98)00860-0

Reference yield:

: 181771-83-5
(R)-8a-(2-Iodo-ethyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

: 210834-68-7
Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 99 percent

2: 70 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

3: SmI₂ / tetrahydrofuran / 0 °C

4: dimethylformamide / 80 °C

5: TBAF, SiO₂ / CHCl₃

6: KHMDS / tetrahydrofuran / -78 °C

7: TBAF / tetrahydrofuran

8: KHMDS / tetrahydrofuran / -78 °C

9: KHMDS / tetrahydrofuran / -78 °C

10: TBAF / tetrahydrofuran

With n-butyllithium; samarium diiodide; tetrabutyl ammonium fluoride; silica gel; potassium hexamethylsilazane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00860-0

Reference yield:

: 182209-18-3
(1S,7aR)-7a-Methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-1-carbonitrile

: 210834-68-7
Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-3a-hydroxy-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 11 steps

1: O₃, AcOH / ethyl acetate

2: ethyl acetate

3: 70 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

4: SmI₂ / tetrahydrofuran / 0 °C

5: dimethylformamide / 80 °C

6: TBAF, SiO₂ / CHCl₃

7: KHMDS / tetrahydrofuran / -78 °C

8: TBAF / tetrahydrofuran

9: KHMDS / tetrahydrofuran / -78 °C

10: KHMDS / tetrahydrofuran / -78 °C

11: TBAF / tetrahydrofuran

With n-butyllithium; samarium diiodide; tetrabutyl ammonium fluoride; silica gel; potassium hexamethylsilazane; ozone; acetic acid; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00860-0