Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester
CAS No.:210834-67-6
Molecular Formula:C₃₁H₄₀F₃NO₆S₂Si
Molecular Weight:671.874
Hs Code.:

Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

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Technology Process of Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

There total 12 articles about Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1026450-31-6
(1S,3aS,4S,7aR)-7a-Methyl-5-oxo-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-octahydro-indene-1-carbonitrile

: 210834-67-6
Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; Yield given;
DOI:10.1016/S0040-4039(98)00860-0

Reference yield:

: 181771-83-5
(R)-8a-(2-Iodo-ethyl)-6,7,8,8a-tetrahydro-4H-benzo[1,3]dioxine

: 210834-67-6
Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 99 percent

2: 70 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

3: SmI₂ / tetrahydrofuran / 0 °C

4: dimethylformamide / 80 °C

5: TBAF, SiO₂ / CHCl₃

6: KHMDS / tetrahydrofuran / -78 °C

7: TBAF / tetrahydrofuran

8: KHMDS / tetrahydrofuran / -78 °C

9: KHMDS / tetrahydrofuran / -78 °C

With n-butyllithium; samarium diiodide; tetrabutyl ammonium fluoride; silica gel; potassium hexamethylsilazane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00860-0

Reference yield:

: 182209-18-3
(1S,7aR)-7a-Methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-1-carbonitrile

: 210834-67-6
Trifluoro-methanesulfonic acid (1S,3aS,4S,7aR)-1-cyano-7a-methyl-6-phenylsulfanyl-4-[(R)-2-(4,6,7,8-tetrahydro-benzo[1,3]dioxin-8a-yl)-ethyl]-3a-trimethylsilanyloxy-2,3,3a,4,7,7a-hexahydro-1H-inden-5-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1: O₃, AcOH / ethyl acetate

2: ethyl acetate

3: 70 percent / n-BuLi / tetrahydrofuran / -78 - 0 °C

4: SmI₂ / tetrahydrofuran / 0 °C

5: dimethylformamide / 80 °C

6: TBAF, SiO₂ / CHCl₃

7: KHMDS / tetrahydrofuran / -78 °C

8: TBAF / tetrahydrofuran

9: KHMDS / tetrahydrofuran / -78 °C

10: KHMDS / tetrahydrofuran / -78 °C

With n-butyllithium; samarium diiodide; tetrabutyl ammonium fluoride; silica gel; potassium hexamethylsilazane; ozone; acetic acid; In tetrahydrofuran; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00860-0