benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate
CAS No.:1426154-26-8
Molecular Formula:C₂₂H₂₇ClN₄O₅S
Molecular Weight:494.999
Hs Code.:

Synonyms:benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate

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Chemical Property of benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate

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Technology Process of benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate

There total 7 articles about benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 287953-54-2
4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester

: 1101818-26-1
4-[2-chloro-6-(iodomethyl)pyrimidin-4-yl]morpholine

: 1426154-26-8
benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate

Guidance literature:: 4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester; With sodium carbonate; sodium sulfite; at 50 ℃; for 18h; Inert atmosphere;

4-[2-chloro-6-(iodomethyl)pyrimidin-4-yl]morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm301859s

Reference yield: 64.6%

: 1101818-26-1
4-[2-chloro-6-(iodomethyl)pyrimidin-4-yl]morpholine

: 1616974-33-4
sodium 1-[(benzyloxy)carbonyl]piperidine-4-sulfinate

: 1426154-26-8
benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.04.111

Reference yield:

: 6299-85-0
2,6-dichloropyrimidine-4-carboxylic acid methyl ester

: 1426154-26-8
benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 4 h / -5 - 0 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran / 3.5 h / -5 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4.1: sodium iodide / acetone / 2 h / 20 °C / Inert atmosphere

5.1: sodium sulfite; sodium carbonate / 18 h / 50 °C / Inert atmosphere

5.2: 16 h / 20 °C / Inert atmosphere

With lithium borohydride; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium sulfite; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm301859s