4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid

Base Information

Chemical Name:4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid
CAS No.:132047-11-1
Molecular Formula:C₁₈H₂₇F₂O₅P
Molecular Weight:392.38
Hs Code.:

Synonyms:4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid

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Chemical Property of 4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid

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Technology Process of 4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid

There total 8 articles about 4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132047-19-9
1,1-difluoro-2-dicanyl phenylacetate

: 132047-11-1
4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (+) hapten 4, aq. Na₂HPO₄, aq. KH₂PO₄ / 15 h / 25 - 27 °C / pH 7.3

2: pyridine / CH₂Cl₂

3: 0.1 M aq. NaOH / 50 °C

With pyridine; sodium hydroxide; disodium hydrogenphosphate; potassium dihydrogenphosphate; (+) hapten 4; In dichloromethane;
DOI:10.1021/ja00006a032

Reference yield:

: 132047-10-0
4-[Bis-((R)-1-difluoromethyl-nonyloxy)-phosphorylmethyl]-benzoic acid (R)-1-difluoromethyl-nonyl ester

: 132047-11-1
4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid

Guidance literature:: With sodium hydroxide; at 50 ℃; Yield given;
DOI:10.1021/ja00006a032

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 132047-11-1
4-[((R)-1-Difluoromethyl-nonyloxy)-hydroxy-phosphorylmethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / 5 h / 200 °C

2: conc. HCl / 1 h / Heating

3: thionyl chloride

4: pyridine / CH₂Cl₂

5: 0.1 M aq. NaOH / 50 °C

With pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; In dichloromethane;
DOI:10.1021/ja00006a032