3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile

Base Information

• Chemical Name: 3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile
• CAS No.: 135126-92-0
• Molecular Formula: C₂₅H₁₉N₃O₂
• Molecular Weight: 393.445
• Mol file: 135126-92-0.mol

Synonyms:3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile

Chemical Property of 3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile

There total 1 articles about 3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-benzoyloxy-3,5-diphenyl-1H-pyrazole (130188-18-0) + acrylonitrile (107-13-1,25014-41-9) → 3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile (135126-92-0)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In 1,4-dioxane; water; at 70 ℃; for 1h;

Reference yield: 70.0%

3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile (135126-92-0) → 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)propanoic acid (135126-93-1)

Guidance literature:

With hydrogenchloride; for 3h; Heating;

Reference yield:

3-(4-benzoyloxy-3,5-diphenyl-1H-pyrazol-1-yl)propanonitrile (135126-92-0) → 1-(3-Diethylamino-propyl)-3,5-diphenyl-1H-pyrazol-4-ol (135127-01-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / conc. HCl / 3 h / Heating

2: 84 percent / gas. HCl / 48 h / Ambient temperature

3: 65 percent / 18 h / 100 °C

4: 80 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran;

upstream raw materials:

4-benzoyloxy-3,5-diphenyl-1H-pyrazole

acrylonitrile

Downstream raw materials:

3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)propanoic acid

methyl 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)propanoate

1-(3-Diethylamino-propyl)-3,5-diphenyl-1H-pyrazol-4-ol

3,5-Diphenyl-1-(3-pyrrolidin-1-yl-propyl)-1H-pyrazol-4-ol