(4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Base Information

Chemical Name:(4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone
CAS No.:1622173-22-1
Molecular Formula:C₃₆H₃₄N₆O₃
Molecular Weight:598.704
Hs Code.:

Synonyms:(4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Suppliers and Price of (4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

There total 6 articles about (4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1622173-55-0
(4-((6-(1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

: 1710-98-1
p-tert-butyl benzoyl chloride

: 1622173-22-1
(4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1622173-22-1
(4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 110 °C

4: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere

5: potassium carbonate / acetonitrile / 2 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 5397-76-2
1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone

: 1622173-22-1
(4-((6-(1-(4-(tert-butyl)benzoyl)-1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 110 °C

3: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 12 h / 110 °C / Inert atmosphere

4: potassium carbonate / acetonitrile / 2 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;