3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Chemical Name:3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide
CAS No.:1450789-81-7
Molecular Formula:C₃₅H₂₈F₃N₅O₆S*ClH
Molecular Weight:740.159
Hs Code.:

Synonyms:3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Chemical Property of 3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Technology Process of 3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

There total 8 articles about 3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1450789-72-6
tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

: 1450789-81-7
3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/ml400217r

Reference yield:

: 1450789-66-8
2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

: 1450789-81-7
3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C / pH > 10

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ml400217r

Reference yield:

: 591-19-5
m-Bromoaniline

: 1450789-81-7
3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: tri tert-butylphosphoniumtetrafluoroborate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 25 h / 140 °C / Microwave irradiation

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C / pH > 10

3: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ml400217r