4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

Base Information

Chemical Name:4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline
CAS No.:1101817-88-2
Molecular Formula:C₂₄H₂₅FN₄O₃S
Molecular Weight:468.552
Hs Code.:

Synonyms:4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

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Chemical Property of 4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

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Technology Process of 4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

There total 8 articles about 4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1101817-90-6
2-chloro-4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 1101817-88-2
4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; at 80 - 95 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jm501778s

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1101817-88-2
4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / 20 h / 50 °C

5: acetonitrile / 20 h / 80 °C / Inert atmosphere

6: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

7: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; lithium borohydride; tetrabutylammomium bromide; sodium carbonate; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s

Reference yield:

: 1009628-23-2
(S)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methyl methanesulfonate

: 1101817-88-2
4-[4-[1-(4-fluorophenyl)sulfonylcyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / 20 h / 50 °C

2: acetonitrile / 20 h / 80 °C / Inert atmosphere

3: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; sodium carbonate; sodium iodide; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s