benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite

Base Information

Chemical Name:benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite
CAS No.:1380522-06-4
Molecular Formula:C₃₃H₆₀NO₅P
Molecular Weight:581.817
Hs Code.:

Synonyms:benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite

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Chemical Property of benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite

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Technology Process of benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite

There total 7 articles about benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: (R)-methyl 2-(hexadecyloxy)-3-hydroxypropanoate

: 1380522-06-4
benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite

Guidance literature:: With 1H-tetrazole; In acetonitrile; at 0 - 20 ℃; for 0.25h;
DOI:10.1021/ja302099u

Reference yield:

: 1380522-03-1
(S)-tert-butyl(2-hexadecyloxy-3-(4-methoxybenzyloxy)propoxy)diphenylsilane

: 1380522-06-4
benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 3 h / 5 - 10 °C / pH 7 / aq. phosphate buffer

2: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C

3: methanol; hexane; dichloromethane / 0.5 h / -78 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

5: 1H-tetrazole / acetonitrile / 0.25 h / 0 - 20 °C

With 1H-tetrazole; dipyridinium dichromate; tetrabutyl ammonium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja302099u

Reference yield:

: 56183-63-2
bis(diisopropylamino)chlorophosphine

: 1380522-06-4
benzyl [(R)-2-methoxycarbonyl-2-hexadecyloxyethyl] diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / diethyl ether / 2 h / 0 - 20 °C

2: 1H-tetrazole / acetonitrile / 0.25 h / 0 - 20 °C

With 1H-tetrazole; triethylamine; In diethyl ether; acetonitrile;
DOI:10.1021/ja302099u