9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester

Base Information

• Chemical Name: 9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester
• CAS No.: 1190367-19-1
• Molecular Formula: C₂₆H₂₄ClNO₃
• Molecular Weight: 433.934
• Mol file: 1190367-19-1.mol

Synonyms:9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester

Chemical Property of 9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester

There total 2 articles about 9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-allyloxy-4-(allyl-phenyl-amino)-4'-chloro-3-methyl-biphenyl-2-carboxylic acid ethyl ester (1190367-03-3) → 9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester (1190367-19-1)

Guidance literature:

With Grubbs catalyst first generation; In dichloromethane; at 25 ℃; Inert atmosphere;

DOI:10.1039/b910397j

Reference yield:

6-(4-chlorophenyl)-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester (89951-61-1) + allyl bromide (106-95-6) + Nitrosobenzene (586-96-9) → 9-(4-chlorophenyl)-6-(4-hydroxyphenyl)-7-methyl-5,6-dihydro-2H-benzo[b] [1,4]oxazocine-8-carboxylic acid ethyl ester (1190367-19-1)

Guidance literature:

6-(4-chlorophenyl)-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester; With piperidine; at 25 ℃; for 0.5h;

Nitrosobenzene; at 25 ℃; for 1h;

allyl bromide; Further stages;

DOI:10.1080/07391102.2016.1216895

upstream raw materials:

5-allyloxy-4-(allyl-phenyl-amino)-4'-chloro-3-methyl-biphenyl-2-carboxylic acid ethyl ester

6-(4-chlorophenyl)-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester

allyl bromide

Nitrosobenzene