methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

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Chemical Name:methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester
CAS No.:869588-24-9
Molecular Formula:C₂₆H₂₄FNO₅S
Molecular Weight:481.545
Hs Code.:

Synonyms:methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

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Chemical Property of methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

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Technology Process of methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

There total 3 articles about methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 869588-23-8
methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

: 459-23-4,7304-35-0
4-fluorobenzaldoxime

: 869588-24-9
methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

Guidance literature:: methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester; With ethylmagnesium bromide; isopropyl alcohol; In dichloromethane; at 0 - 23 ℃;

4-fluorobenzaldoxime; With tert-butylhypochlorite; In dichloromethane; at -78 - 23 ℃;

In dichloromethane; at 23 ℃; for 30h;
DOI:10.1039/b510100j

Reference yield:

: methanesulfonic acid 4-[(E)-3-hydroxyhexa-1,5-dienyl]phenyl ester

: 869588-24-9
methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 51 percent / PPh₃; Et₃N / Pd(OAc)2 / acetonitrile / 4 h / Heating

2.1: EtMgBr; i-PrOH / CH₂Cl₂ / 0 - 23 °C

2.2: tert-butyl hypochlorite / CH₂Cl₂ / -78 - 23 °C

2.3: 36 percent / CH₂Cl₂ / 30 h / 23 °C

With ethylmagnesium bromide; triethylamine; triphenylphosphine; isopropyl alcohol; palladium diacetate; In dichloromethane; acetonitrile; 1.1: Heck arylation;
DOI:10.1039/b510100j

Reference yield:

: 591-50-4
iodobenzene

: 869588-24-9
methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 51 percent / PPh₃; Et₃N / Pd(OAc)2 / acetonitrile / 4 h / Heating

2.1: EtMgBr; i-PrOH / CH₂Cl₂ / 0 - 23 °C

2.2: tert-butyl hypochlorite / CH₂Cl₂ / -78 - 23 °C

2.3: 36 percent / CH₂Cl₂ / 30 h / 23 °C

With ethylmagnesium bromide; triethylamine; triphenylphosphine; isopropyl alcohol; palladium diacetate; In dichloromethane; acetonitrile; 1.1: Heck arylation;
DOI:10.1039/b510100j