methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

Base Information

Chemical Name:methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester
CAS No.:869588-23-8
Molecular Formula:C₁₉H₂₀O₄S
Molecular Weight:344.431
Hs Code.:

Synonyms:methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

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Chemical Property of methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

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Technology Process of methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

There total 1 articles about methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: methanesulfonic acid 4-[(E)-3-hydroxyhexa-1,5-dienyl]phenyl ester

: 591-50-4
iodobenzene

: 869588-23-8
methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

Guidance literature:: With triethylamine; triphenylphosphine; palladium diacetate; In acetonitrile; for 4h; Heating;
DOI:10.1039/b510100j

Reference yield: 36.0%

: 869588-23-8
methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

: 459-23-4,7304-35-0
4-fluorobenzaldoxime

: 869588-24-9
methanesulfonic acid 4-{(4S,5S)-3-(4-fluorophenyl)-5-[(E)-(S)-1-hydroxy-4-phenylbut-3-enyl]-4,5-dihydroisoxazol-4-yl}phenyl ester

Guidance literature:: methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester; With ethylmagnesium bromide; isopropyl alcohol; In dichloromethane; at 0 - 23 ℃;

4-fluorobenzaldoxime; With tert-butylhypochlorite; In dichloromethane; at -78 - 23 ℃;

In dichloromethane; at 23 ℃; for 30h;
DOI:10.1039/b510100j

Reference yield:

: 869588-23-8
methanesulfonic acid 4-[(1E,5E)-(S)-3-hydroxy-6-phenylhexa-1,5-dienyl]phenyl ester

: Methanesulfonic acid 4-{(4S,5R)-3-(4-fluoro-phenyl)-5-[3-(4-fluoro-phenyl)-3-oxo-propyl]-4,5-dihydro-isoxazol-4-yl}-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: EtMgBr; i-PrOH / CH₂Cl₂ / 0 - 23 °C

1.2: tert-butyl hypochlorite / CH₂Cl₂ / -78 - 23 °C

1.3: 36 percent / CH₂Cl₂ / 30 h / 23 °C

2.1: pyridine / CH₂Cl₂ / 16 h / 23 °C

3.1: DBU / CH₂Cl₂ / 12 h / Heating

3.2: aq. NaIO₄; K₂OsO₄ / tetrahydrofuran / 14 h

4.1: CH₂Cl₂ / 0.5 h / 23 °C

5.1: H₂ / Pd/C / methanol / 0.17 h / 23 °C / 760 Torr

With pyridine; ethylmagnesium bromide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; isopropyl alcohol; palladium on activated charcoal; In methanol; dichloromethane; 4.1: Wittig reaction;
DOI:10.1039/b510100j