[2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester

Base Information

• Chemical Name: [2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester
• CAS No.: 475631-84-6
• Molecular Formula: C₂₅H₂₀O₅
• Molecular Weight: 400.431
• Mol file: 475631-84-6.mol

Synonyms:[2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester

Chemical Property of [2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester

There total 1 articles about [2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6) + anisindione (117-37-3) → [2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester (475631-84-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.25h;

DOI:10.1016/S0960-894X(02)00985-X

Reference yield: 74.0%

[2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester (475631-84-6) → [2-(4-methoxy-phenyl)-indan-2-yl]-phenyl-acetic acid (475631-85-7)

Guidance literature:

With hydrogen; acetic acid; palladium dihydroxide; In ethanol; ethyl acetate; for 68h;

DOI:10.1016/S0960-894X(02)00985-X

Reference yield:

[2-(4-methoxy-phenyl)-1,3-dioxo-indan-2-yl]-phenyl-acetic acid methyl ester (475631-84-6) → C24H20O (551929-12-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 74 percent / H₂; AcOH / Pd(OH)2/C / ethyl acetate; ethanol / 68 h

2: PCl₅ / CH₂Cl₂ / 1 h / 0 °C

3: AlCl₃ / CH₂Cl₂ / 0.75 h / 0 °C

4: NaBH₄ / methanol; tetrahydrofuran / 14 h

5: TsOH / benzene / 12 h / Heating

With sodium tetrahydroborate; aluminium trichloride; phosphorus pentachloride; hydrogen; toluene-4-sulfonic acid; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; benzene; 3: Friedel-Crafts cyclization;

DOI:10.1016/S0960-894X(02)00985-X

upstream raw materials:

bromo-phenyl-acetic acid methyl ester

anisindione

Downstream raw materials:

[2-(4-methoxy-phenyl)-indan-2-yl]-phenyl-acetic acid

C₂₄H₂₀O

C₂₄H₂₀O₂