2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)

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Chemical Name:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)
CAS No.:1443300-22-8
Molecular Formula:C₃₃H₄₈N₂O₁₂
Molecular Weight:664.75
Hs Code.:

Synonyms:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)

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Chemical Property of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)

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Technology Process of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)

There total 14 articles about 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443052-79-6
ethyl 5-(dimethylcarbamoyl)-3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: C₈H₁₅ClO₃

: 1443300-22-8
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)

Guidance literature:: With triethylamine; In dichloromethane; for 0.75h;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1443300-22-8
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)

Guidance literature:: Multi-step reaction with 6 steps

1: sodium acetate; sodium iodide / water / 3 h / 90 °C

2: water; sodium hydroxide / tetrahydrofuran; ethanol / 3 h / 40 °C

3: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C

5: sodium ethanolate / ethanol / 1.5 h / 85 °C

6: triethylamine / dichloromethane / 0.75 h

With water; sodium ethanolate; sodium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1218915-70-8
methyl 3-(2-methoxyethoxy)-2,2-dimethylpropanoate

: 1443300-22-8
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate)

Guidance literature:: Multi-step reaction with 3 steps

1: water; potassium hydroxide / 72 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h

3: triethylamine / dichloromethane / 0.75 h

With oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In dichloromethane;