2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

Base Information

Chemical Name:2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine
CAS No.:182867-77-2
Molecular Formula:C₁₀H₉Cl₂FN₂O
Molecular Weight:263.099
Hs Code.:

Synonyms:2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

Suppliers and Price of 2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

There total 1 articles about 2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 182867-77-2
2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / SOCl₂, DMF / toluene / 3 h / 85 °C

2: 96 percent / CH₂Cl₂ / 3 h / Ambient temperature

3: 87 percent / SOCl₂ / CH₂Cl₂ / 22.5 h / Ambient temperature

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1016/0968-0896(96)00106-X

Reference yield:

: 182867-77-2
2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

: C₂₁H₁₇F₂N₃O₄*ClH

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) THF, 0 deg C, 30 min

2: 66 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: 45 percent / NaH / tetrahydrofuran / Heating

4: 10percent aq. HCl / 22 h / 90 - 95 °C

5: dioxane / 1 h / Ambient temperature

6: 100 percent / SOCl₂, DMF / 2.5 h / Ambient temperature

7: 1.) LDA / 1.) -78 deg C, 2.) from -78 deg C to 0 deg C

8: Ac₂O / Heating

9: CH₂Cl₂ / 2 h / Ambient temperature

10: 47 percent / NaH / tetrahydrofuran / 0.83 h / 45 - 50 °C

11: 48 percent / 4N aq. HCl / Heating

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; acetic anhydride; sodium hydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1016/0968-0896(96)00106-X

Reference yield:

: 182867-77-2
2,6-Dichloro-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-fluoro-pyridine

: 182868-12-8
C₂₀H₁₉ClN₂O₅

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, -78 deg C, 15 min, 2.) THF, 0 deg C, 30 min

2: 66 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: 45 percent / NaH / tetrahydrofuran / Heating

4: 10percent aq. HCl / 22 h / 90 - 95 °C

5: dioxane / 1 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether;
DOI:10.1016/0968-0896(96)00106-X