(1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid

Base Information

Chemical Name:(1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid
CAS No.:323196-40-3
Molecular Formula:C₁₂H₁₉NO₄
Molecular Weight:241.287
Hs Code.:

Synonyms:(1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid

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Chemical Property of (1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid

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Technology Process of (1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid

There total 3 articles about (1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 323196-39-0
(1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid methyl ester

: 323196-40-3,1226812-50-5,63216-52-4,865689-24-3
(1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 78h;
DOI:10.1016/S0040-4039(00)01576-8

Reference yield:

: 323196-38-9
(1R,2R)-cyclohex-4-ene 1,2-dicarboxylic acid monomethyl ester

: 323196-40-3,1226812-50-5,63216-52-4,865689-24-3
(1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / DPPA; Et₃N

2: 98 percent / LiOH*H₂O; H₂O / tetrahydrofuran / 78 h / 20 °C

With lithium hydroxide; diphenyl-phosphinic acid; water; triethylamine; In tetrahydrofuran; 1: Curtius rearrangement / 2: Hydrolysis;
DOI:10.1016/S0040-4039(00)01576-8

Reference yield:

: 116733-43-8
(1R,6R)-6-(2-oxo-oxazolidine-3-carbonyl)-cyclohex-3-ene carboxylic acid methyl ester

: 323196-40-3,1226812-50-5,63216-52-4,865689-24-3
(1R,6R)-6-tert-butoxycarbonylamino-cyclohex-3-ene carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / H₂O; H₂O₂; LiOH*H₂O / tetrahydrofuran / 18 h / 20 °C

2: 74 percent / DPPA; Et₃N

3: 98 percent / LiOH*H₂O; H₂O / tetrahydrofuran / 78 h / 20 °C

With lithium hydroxide; diphenyl-phosphinic acid; water; dihydrogen peroxide; triethylamine; In tetrahydrofuran; 1: Hydrolysis / 2: Curtius rearrangement / 3: Hydrolysis;
DOI:10.1016/S0040-4039(00)01576-8