4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

Base Information

Chemical Name:4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one
CAS No.:181795-86-8
Molecular Formula:C₁₃H₁₃F₃N₂OS
Molecular Weight:302.32
Hs Code.:

Synonyms:4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

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Chemical Property of 4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

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Technology Process of 4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

There total 3 articles about 4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 152595-60-3
ethyl-α-(trifluoroacetyl)-3-(4-methylthiophenyl) propionate

: 181795-86-8
4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

Guidance literature:: With 3 A molecular sieve; hydrazine; In toluene; Heating;
DOI:10.1021/jm960444z

Reference yield:

: 3446-90-0
4-(methylthio)benzyl alcohol

: 181795-86-8
4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / carbon tetrabromide, triphenylphosphine / CH₂Cl₂ / 0 - 20 °C

2: 55 percent / NaH / 1,2-dimethoxy-ethane / 15 h / Heating

3: 30 percent / hydrazine, 3 Angstroem molecular sieves / toluene / Heating

With carbon tetrabromide; 3 A molecular sieve; sodium hydride; triphenylphosphine; hydrazine; In 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1021/jm960444z

Reference yield:

: 38185-19-2
4-(methylthio)benzyl bromide

: 181795-86-8
4-Methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-2,4-dihydro-pyrazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / NaH / 1,2-dimethoxy-ethane / 15 h / Heating

2: 30 percent / hydrazine, 3 Angstroem molecular sieves / toluene / Heating

With 3 A molecular sieve; sodium hydride; hydrazine; In 1,2-dimethoxyethane; toluene;
DOI:10.1021/jm960444z