ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate

Base Information

• Chemical Name: ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate
• CAS No.: 511533-35-0
• Molecular Formula: C₁₃H₁₁ClO₄
• Molecular Weight: 266.681
• Mol file: 511533-35-0.mol

Synonyms:ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate

Chemical Property of ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate

There total 1 articles about ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-2,3-dihydro-1H-inden-1-one (51135-91-2) → ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate (511533-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / NaNO₂; CuCl; HCl / H₂O / 2 h / 0 - 20 °C

2: 69 percent / Na / ethanol / 2 h / 20 °C

With hydrogenchloride; sodium; copper(l) chloride; sodium nitrite; In ethanol; water;

DOI:10.1016/S0968-0896(02)00319-X

Reference yield: 63.0%

2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) + ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate (511533-35-0) → ethyl 5-chloro-1-(2',4'-dichlorophenyl)-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylate (511533-23-6)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1016/S0968-0896(02)00319-X

Reference yield:

ethyl β-(4-chloro-1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate (511533-35-0) → 5-chloro-1-(2',4'-dichlorophenyl)-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylic acid (511533-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / ethanol / 2 h / Heating

2: 96 percent / KOH / methanol / Heating

With potassium hydroxide; In methanol; ethanol;

DOI:10.1016/S0968-0896(02)00319-X

upstream raw materials:

4-amino-2,3-dihydro-1H-inden-1-one

Downstream raw materials:

ethyl 5-chloro-1-(2',4'-dichlorophenyl)-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylate

5-chloro-1-(2',4'-dichlorophenyl)-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylic acid