51135-91-2

Basic information

• Product Name: 4-AMINO-1-INDANONE
• Synonyms: 4-AMINO-INDAN-1-ONE;4-AMINO-1-INDANONE;4-amino-2,3-dihydroinden-1-one;4-aminoindanone;4-amino-2,3-dihydro-1H-inden-1-one;1-Indanone, 4-aMino-
• CAS NO: 51135-91-2
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Mol File: 51135-91-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 122-123 °C
• Boiling Point: 323.177 °C at 760 mmHg
• Flash Point: 149.252 °C
• Appearance: /
• Density: 1.255 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.65
• PKA: 3.20±0.20(Predicted)
• CAS DataBase Reference: 4-AMINO-1-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-INDANONE(51135-91-2)
• EPA Substance Registry System: 4-AMINO-1-INDANONE(51135-91-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 51135-91-2(Hazardous Substances Data)

Usage

General Description

4-AMINO-1-INDANONE is a chemical compound that contains an indanone ring system with an amino group attached at position 4. It is used in the synthesis of various pharmaceuticals and as a building block for organic synthesis. 4-AMINO-1-INDANONE is known for its potential pharmacological properties and has been studied for its potential as a therapeutic agent in the treatment of various diseases. Its structure and properties make it a versatile compound with potential applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C9H9NO/c10-8-3-1-2-7-6(8)4-5-9(7)11/h1-3H,4-5,10H2

Upstream product

• 24623-25-4 4-nitro-2,3-dihydro-1H-inden-1-one 
• 34701-14-9 4-nitroindane 
• 83-33-0 inden-1-one 
• 24623-24-3 6-nitroindan-1-one 
• 645-45-4 hydrocinnamic acid chloride 
• 85397-21-3 3-(2-nitro-phenyl)-propionyl chloride 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 861325-73-7 2,2-dibromo-4-nitro-indan-1-one 

Downstream Products

• 173252-63-6 N-(1-oxo-indan-4-yl)-acetamide 
• 60899-32-3 4-iodo-2,3-dihydro-1H-inden-1-ol 
• 1190482-07-5 6-chloro-N-(1-oxo-2,3-dihydro-1H-inden-4-yl)imidazo[2,1-b][1,3]thiazole-5-sulfonamide 

Relevant articles and documents

Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation

Successes have been achieved in developing human monoamine oxidase B (hMAO-B) inhibitors as anti-Parkinson's disease (PD) drugs. However, low efficiency and unwanted side effects of the marketed hMAO-B inhibitors hamper their medical applications, therefore, novel potent selective hMAO-B inhibitors are still of great interest. Herein we report 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as hMAO-B inhibitors, which were designed by employing a fragment-based drug design strategy to link rasagiline to hydrophobic fragments. Among the synthesized 31 compounds, K8 and K24 demonstrated very encouraging hMAO-B inhibitory activities and selectivity over hMAO-A, better than rasagiline and safinamide. In vitro studies indicated that K8 and K24 are nontoxic to nervous tissue cells and they have considerable effects against ROS formation and potential neuroprotective activity. Further mice behavioral tests demonstrated these two compounds have good therapeutic effects on MPTP-induced PD model mice. All these experiment results suggest that compounds K8 and K24 can be promising candidates for further research for treatment of PD.

COVALENT TARGETING OF E3 LIGASES

Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.

METHODS FOR MAKING QUINOLINYLDIAMINES

The present disclosure provides methods for making quinolinyldiamine products from quinolinyl starting materials. In addition, the quinolinyldiamines can be used as ligands or ligand precursors for catalysts, e.g. for use in olefin polymerization.