trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one

Base Information

• Chemical Name: trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one
• CAS No.: 1026511-09-0
• Molecular Formula: C₁₆H₁₃FO₂
• Molecular Weight: 256.276
• Mol file: 1026511-09-0.mol

Synonyms:trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one

Chemical Property of trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one

There total 2 articles about trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(4-fluorophenyl)-1-p-tolylprop-2-en-1-one (13565-38-3,102692-48-8,98991-33-4) → trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one (1026511-09-0)

Guidance literature:

3-(4-fluorophenyl)-1-p-tolylprop-2-en-1-one; With C₂₈H₃₄F₆MnN₆O₆S₂; acetic acid; In acetonitrile; for 0.0833333h; Inert atmosphere;

With dihydrogen peroxide; In acetonitrile; at -20 - 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201103802

Reference yield:

3-(4-fluorophenyl)-1-p-tolylprop-2-en-1-one (13565-38-3,102692-48-8,98991-33-4) → trans-(2S,3R)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one (1181811-21-1) + trans-(2R,3S)-2,3-epoxy-1-(4-methylphenyl)-3-(4-fluorophenyl)propan-1-one (1026511-09-0)

Guidance literature:

With C₄₂H₅₂F₆MnN₄O₆S₂; dihydrogen peroxide; acetic acid; In acetonitrile; at 20 ℃; for 1h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol901400m

upstream raw materials:

3-(4-fluorophenyl)-1-p-tolylprop-2-en-1-one