N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester
CAS No.:366792-99-6
Molecular Formula:C₁₈H₂₆N₄O₆
Molecular Weight:394.428
Hs Code.:

<i>N</i>'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid <i>tert</i>-butyl ester

Synonyms:N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

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Chemical Property of N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

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Technology Process of N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

There total 1 articles about N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23776-83-2
N'-(2-aminoacetyl)hydrazinecarboxylic acid tert-butyl ester

: 39608-31-6
N-(Benzyloxycarbonyl)sarcosine

: 366792-99-6
N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol016440s

Reference yield:

: 366792-99-6
N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

: 366793-06-8
(4aR,19S,20S)-6-Benzyloxy-19-isopropyl-9,15-dimethyl-5,8,11,14,17,21-hexaoxo-20-(2,2,2-trichloro-ethoxycarbonylamino)-octadecahydro-18-oxa-1,6,9,12,15,21a-hexaaza-benzocyclononadecene-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 8 h / 20 °C

2.1: BOP-Cl; Et₃N / CH₂Cl₂ / -20 - 0 °C

3.1: 87 percent / Et₂NH / acetonitrile / 0.33 h / 20 °C

4.1: AgCN / benzene / 0.05 h / 75 - 80 °C

5.1: CH₂Cl₂ / 2 h / 20 °C

5.2: NBS; H₂O / tetrahydrofuran / 2 h / 20 °C

6.1: NEM; HATU / CH₂Cl₂ / 0 - 20 °C

With N-Ethylmaleimide; silver cyanide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 20percent Pd(OH)2/C; In methanol; dichloromethane; acetonitrile; benzene;
DOI:10.1021/ol016440s

Reference yield:

: 366792-99-6
N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

: 366793-00-2
3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 8 h / 20 °C

2: BOP-Cl; Et₃N / CH₂Cl₂ / -20 - 0 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; 20percent Pd(OH)2/C; In methanol; dichloromethane;
DOI:10.1021/ol016440s