(R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester

Base Information

Chemical Name:(R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester
CAS No.:75369-73-2
Molecular Formula:C₁₉H₂₈O₆S
Molecular Weight:384.494
Hs Code.:

Synonyms:(R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester

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Technology Process of (R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester

There total 3 articles about (R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 10150-87-5
1-acetoxybutan-3-one

: 58059-08-8
tert-butyl (R)-p-toluenesulfinylacetate

: 75369-73-2
(R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester

Guidance literature:: With tert-butylmagnesium bromide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/0040-4020(80)80010-X

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 75369-73-2
(R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (iPr)2NMgBr; 2) NH₄Cl / 1) THF, ether, -40 to -35 deg C

2: 90 percent / t-BuMgBr / tetrahydrofuran / -78 °C

With bromomagnesium diisopropylamide; tert-butylmagnesium bromide; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80010-X

Reference yield:

: 1517-82-4,13064-80-7,20752-45-8,50444-99-0,83060-18-8,83060-21-3,91177-13-8,91796-57-5,98147-48-9,124819-73-4,132829-99-3,134929-63-8
(-)S sulfinate de menthyle

: 75369-73-2
(R)-5-Acetoxy-3-hydroxy-3-methyl-2-((R)-toluene-4-sulfinyl)-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (iPr)2NMgBr; 2) NH₄Cl / 1) THF, ether, -40 to -35 deg C

2: 90 percent / t-BuMgBr / tetrahydrofuran / -78 °C

With bromomagnesium diisopropylamide; tert-butylmagnesium bromide; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80010-X