2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide

Base Information

• Chemical Name: 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide
• CAS No.: 359844-90-9
• Molecular Formula: C₁₆H₁₈ClN₃O₂
• Molecular Weight: 319.791
• Mol file: 359844-90-9.mol

Synonyms:2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide

Chemical Property of 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide

There total 1 articles about 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-iodo-2-methylpyridazin-3(2H)-one (153239-91-9) + 5-chloro-2-(pivaloylamino)benzeneboronic acid (185950-64-5) → 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide (359844-90-9)

Guidance literature:

5-iodo-2-methylpyridazin-3(2H)-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 20 ℃; for 0.5h;

5-chloro-2-(pivaloylamino)benzeneboronic acid; With sodium carbonate; In 1,2-dimethoxyethane; for 8h; Heating;

Reference yield: 79.0%

2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide (359844-90-9) → 5-(2-amino-5-chlorophenyl)-2-methylpyridazin-3(2H)-one (359844-92-1)

Guidance literature:

With sulfuric acid; for 3h; Heating;

Reference yield:

2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-4-chloro-N-pivaloylanilide (359844-90-9) → 5-(2-azido-5-chlorophenyl)-2-methylpyridazin-3(2H)-one (359844-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 79 percent / 20 percent H₂SO₄ / 3 h / Heating

2.1: NaNO₂; 37 percent HCl / H₂O / 1.5 h / 5 °C

2.2: 90 percent / NaN₃; NaOAc / H₂O / 1 h / 0 - 5 °C

With hydrogenchloride; sulfuric acid; sodium nitrite; In water;

upstream raw materials:

5-iodo-2-methylpyridazin-3(2H)-one

5-chloro-2-(pivaloylamino)benzeneboronic acid

Downstream raw materials:

5-(2-amino-5-chlorophenyl)-2-methylpyridazin-3(2H)-one

5-(2-azido-5-chlorophenyl)-2-methylpyridazin-3(2H)-one

5-(5-chloro-2-triphenylphosphoranylideneaminophenyl)-2-methylpyridazin-3(2H)-one

9-chloro-3-methyl-5-phenylamino-pyridazino[4,5-c]quinolin-4(3H)-one