153239-91-9

Basic information

• Product Name: 5-Iodo-2-Methylpyridazin-3(2h)-one
• Synonyms: 5-Iodo-2-Methylpyridazin-3(2h)-one;5-iodo-2-methyl-2,3-dihydropyridazin-3-one;5-Iodo-2-methyl-3(2H)-pyridazinone
• CAS NO: 153239-91-9
• Molecular Formula: C₅H₅IN₂O
• Molecular Weight: 236.01047
• Product Categories: CMLLYL
• Mol File: 153239-91-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 179-180 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 236.3±43.0 °C(Predicted)
• Appearance: /
• Density: 2.07±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -2.41±0.20(Predicted)
• CAS DataBase Reference: 5-Iodo-2-Methylpyridazin-3(2h)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-2-Methylpyridazin-3(2h)-one(153239-91-9)
• EPA Substance Registry System: 5-Iodo-2-Methylpyridazin-3(2h)-one(153239-91-9)

Safety Data

• Hazardous Substances Data: 153239-91-9(Hazardous Substances Data)

Usage

General Description

5-Iodo-2-Methylpyridazin-3(2h)-one is a chemical compound with the molecular formula C6H5INO and a molecular weight of 249.013 g/mol. It is a heterocyclic compound with a pyridazinone core structure, and it contains an iodine atom and a methyl group. This chemical has potential applications in medicinal chemistry and pharmaceutical research due to its structural features and potential biological activities. It may be used as a building block in the synthesis of novel organic compounds with potential pharmacological properties. Additionally, it may also be used as a reagent in chemical synthesis and organic transformations in the laboratory.

Upstream product

• 933-76-6 4,5-dichloro-2-methyl-3(2H)-pyridazinone 
• 74-88-4 methyl iodide 
• 825633-94-1 5-iodo-2,3-dihydropyridazin-3-one 

Downstream Products

• 359844-89-6 2-[(2H)-2-methyl-3-oxo-5-pyridazinyl]-N-pivaloylanilide 
• 682344-91-8 5-(2-bromophenoxy)-2-methylpyridazin-3(2H)-one 
• 1001619-97-1 C₁₄H₁₂N₂O₃ 
• 1346156-08-8 5-(5-chloro-2-triphenylphosphoranylideneaminophenyl)-2-methylpyridazin-3(2H)-one 
• 1346156-10-2 3-methyl-5-phenylamino-pyridazino[4,5-c]quinolin-4(3H)-one 
• 1346156-13-5 5-[2-(1,6-dihydro-1-methyl-6-oxopyridazin-4-yl)-phenylamino]-3-methylpyridazino[4,5-c]-quinolin-4(3H)-one 
• 1346156-11-3 9-chloro-3-methyl-5-phenylamino-pyridazino[4,5-c]quinolin-4(3H)-one 
• 1346156-14-6 5-[2-(1,6-dihydro-1-methyl-6-oxopyridazin-4-yl)-4-chlorophenyl-amino]-9-chloro-3-methyl-pyridazino[4,5-c]quinolin-4(3H)-one 
• 1395895-71-2 5-(N-phenylaminocarbonyl)-2-methylpyridazin-3(2H)-one 
• 359844-94-3 5-(2-azido-5-chlorophenyl)-2-methylpyridazin-3(2H)-one 
• 359844-92-1 5-(2-amino-5-chlorophenyl)-2-methylpyridazin-3(2H)-one 
• 359844-91-0 5-(2-aminophenyl)-2-methylpyridazin-3(2H)-one 
• 359844-93-2 5-(2-azidophenyl)-2-methylpyridazin-3(2H)-one 
• 682344-96-3 5-[(2-bromophenyl)amino]-2-methylpyridazin-3(2H)-one 

Relevant articles and documents

Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions

In the search for novel antiplatelet agents, convenient and efficient methods for the preparation of 2,5-disubstituted pyridazin-3(2H)-ones are reported that utilise palladium-catalysed cross-coupling reactions. A post-coupling base-promoted isomerisation

NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS

The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge

Synthesis of 5H-pyridazino[4,5-b]indoles and their benzofurane analogues utilizing an intramolecular Heck-type reaction

The title ring systems were prepared from pyridazin-3(2H)-one precursors in novel, efficient pathways. 2-Methylbenzo[b]furo[2,3-d]pyridazin-1(2H)-one was synthesized via a regioselective nucleophilic substitution reaction of a 2-methyl-4,5-dihalopyridazin-3(2H)-one with phenol followed by an intramolecular Heck-type reaction. The same molecule and its 6-phenyl analogue were also prepared via reaction of 2-methyl-5-iodopyridazin-3(2H)-one or 2-methyl-5-chloro-6-phenylpyridazin-3(2H)-one, respectively, with 2-bromophenol or 2-iodophenol followed by Pd-catalyzed cyclodehydrohalogenation. Moreover, a new approach for the synthesis of 2-methyl-2,5-dihydro-1H-pyridazino[4,5-b] indol-1-ones was also elaborated utilizing a Heck-type ring closure reaction on 5-[(2-bromophenyl)amino]-2-methylpyridazin-3(2H)-ones which were obtained via Buchwald-Hartwig amination of 2-methyl-5-halopyridazin-3(2H)-ones with 2-bromoaniline.