(S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate
CAS No.:895917-83-6
Molecular Formula:C₁₃H₁₇ClN₂O₄S
Molecular Weight:332.808
Hs Code.:

Synonyms:(S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate

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Chemical Property of (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate

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Technology Process of (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate

There total 2 articles about (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 104613-64-1
2-amino-4-chloro-5-methyl benzenesulfonyl chloride

: 2133-40-6
L-proline methyl ester monohydrochloride

: 895917-83-6
(S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With pyridine; at 20 ℃; for 4h;
DOI:10.1021/jm060168g

Reference yield:

: 88-51-7
6-amino-4-chloro-meta-toluenesulfonic acid

: 895917-83-6
(S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuryl chloride / CH₂Cl₂ / 1 h / 60 °C

1.2: 2.2 g / thionyl chloride / CH₂Cl₂ / 7 h / 100 °C

2.1: 75 percent / pyridine / 4 h / 20 °C

With pyridine; sulfuryl dichloride; In dichloromethane;
DOI:10.1021/jm060168g