(5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile

Base Information

Chemical Name:(5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile
CAS No.:569328-84-3
Molecular Formula:C₁₆H₁₅ClN₄O₅
Molecular Weight:378.772
Hs Code.:

Synonyms:(5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile

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Chemical Property of (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile

Chemical Property:

Purity/Quality:

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Technology Process of (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile

There total 6 articles about (5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128276-52-8
4,6-dimethoxypyrimidin-2-ylacetonitrile

: 1267952-23-7
2,4-dichloro-6-methoxymethylnitrobenzene

: 569328-84-3
(5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Product distribution / selectivity; Cooling with ice;

Reference yield:

: 1267952-21-5
2,4-dichloro-6-hydroxymethylnitrobenzene

: 569328-84-3
(5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 2.5 h / 20 °C / Cooling with ice

2: sodium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C / Cooling with ice

With sodium hydroxide; tetrabutylammomium bromide; In water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 51-36-5
3,5-dichlorobenzoic acid

: 569328-84-3
(5-chloro-3-methoxymethyl-2-nitrophenyl)(4,6-dimethoxypyrimidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; sulfuric acid / 2.5 h / 20 °C

2: potassium carbonate / acetone / 5 h / 50 °C

3: sodium tetrahydroborate; methanol / tetrahydrofuran / 3.5 h / Reflux

4: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 2.5 h / 20 °C / Cooling with ice

5: sodium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C / Cooling with ice

With methanol; sodium tetrahydroborate; sulfuric acid; nitric acid; potassium carbonate; sodium hydroxide; tetrabutylammomium bromide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene;